Cholesterol Depletion and Genistein as Tools to Promote F508delCFTR Retention at the Plasma Membrane | Zendy

Christina H. Lim | Zendy; Marcel J. C. Bijvelds | Zendy; Alex L. Nigg | Zendy; Kees Schoonderwoerd | Zendy; Adriaan B. Houtsmuller | Zendy; Hugo de Jonge | Zendy; Ben C. Tilly | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Cholesterol Depletion and Genistein as Tools to Promote F508delCFTR Retention at the Plasma Membrane

Author(s) -

Christina H. Lim,

Marcel J. C. Bijvelds,

Alex L. Nigg,

Kees Schoonderwoerd,

Adriaan B. Houtsmuller,

Hugo de Jonge,

Ben C. Tilly

Publication year - 2007

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000107531

Subject(s) - filipin , forskolin , endocytosis , beta cyclodextrins , cholesterol , genistein , chemistry , vesicle , phosphatidylcholine , intracellular , efflux , microbiology and biotechnology , biochemistry , cyclodextrin , biophysics , endocrinology , biology , membrane , cell , in vitro , phospholipid

F508delCFTR-, but not wtCFTR-, expressing fibroblasts resemble Niemann Pick type C cells in the massive intracellular accumulation of free cholesterol. The recruitment and activation of F508delCFTR by cholesterol depletion was studied.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research