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gen B27 and testing for antinuclear antibody and rheumatoid factor were negative. Colonoscopy revealed multiple erosions in colon and rectum, and the biopsy findings were compatible with a diagnosis of ulcerative colitis. We made a diagnosis of ulcerative colitis with secondary peripheral arthritis, and prednisolone therapy was started (60 mg/day). The knee pain soon decreased, and 2 months after the start of the prednisolone therapy, the patient was discharged without anemia or knee pain. Dear Sir, A 32-year-old man was admitted to our hospital because of a 2-week history of episodic bilateral knee pain and fever (38.5 ° C). Physical examination of the patient’s knees revealed moderate effusion (right 1 left), normal appearance of the overlying skin, mild warmth to touch, and a decreased range of motion secondary to pain and swelling. Laboratory data obtained at that time revealed severe anemia (hemoglobin 5.9 g/dl, hematocrit 18.2%, C-reactive protein 18.6 mg/dl). Phenotyping for human leukocyte antiPublished online: August 3, 2007

Knee Pain and Swelling Secondary to Ulcerative Colitis