Knee Pain and Swelling Secondary to Ulcerative Colitis

gen B27 and testing for antinuclear antibody and rheumatoid factor were negative. Colonoscopy revealed multiple erosions in colon and rectum, and the biopsy findings were compatible with a diagnosis of ulcerative colitis. We made a diagnosis of ulcerative colitis with secondary peripheral arthritis, and prednisolone therapy was started (60 mg/day). The knee pain soon decreased, and 2 months after the start of the prednisolone therapy, the patient was discharged without anemia or knee pain. Dear Sir, A 32-year-old man was admitted to our hospital because of a 2-week history of episodic bilateral knee pain and fever (38.5 ° C). Physical examination of the patient’s knees revealed moderate effusion (right 1 left), normal appearance of the overlying skin, mild warmth to touch, and a decreased range of motion secondary to pain and swelling. Laboratory data obtained at that time revealed severe anemia (hemoglobin 5.9 g/dl, hematocrit 18.2%, C-reactive protein 18.6 mg/dl). Phenotyping for human leukocyte antiPublished online: August 3, 2007