Regulation of Human Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Serum- and Glucocorticoid-Inducible Kinase (SGK1) | Zendy

J. Denry Sato | Zendy; M. Christine Chapline | Zendy; Renee Thibodeau | Zendy; Raymond A. Frizzell | Zendy; Bruce A. Stanton | Zendy

Open Access

Regulation of Human Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Serum- and Glucocorticoid-Inducible Kinase (SGK1)

Author(s) -

J. Denry Sato,

M. Christine Chapline,

Renee Thibodeau,

Raymond A. Frizzell,

Bruce A. Stanton

Publication year - 2007

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000104157

Subject(s) - sgk1 , cystic fibrosis transmembrane conductance regulator , regulator , glucocorticoid , cystic fibrosis , kinase , transmembrane protein , medicine , endocrinology , microbiology and biotechnology , biology , cancer research , gene , biochemistry , receptor

Serum- and glucocorticoid-inducible kinase-1 (SGK1) increases CFTR Cl currents in Xenopus oocytes by an unknown mechanism. Because SGK increases the plasma membrane expression of other ion channels, the goal of this paper was to test the hypothesis that SGK1 stimulates CFTR Cl currents by increasing the number of CFTR Cl channels in the plasma membrane.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research