Mechanisms of Resistance of Human Glioma Cells to Apo2 Ligand/TNF-Related Apoptosis-Inducing Ligand | Zendy

Johannes Rieger | Zendy; Brigitte Frank | Zendy; Michael Weller | Zendy; Wolfgang Wick | Zendy

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Mechanisms of Resistance of Human Glioma Cells to Apo2 Ligand/TNF-Related Apoptosis-Inducing Ligand

Author(s) -

Johannes Rieger,

Brigitte Frank,

Michael Weller,

Wolfgang Wick

Publication year - 2007

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000104150

Subject(s) - apoptosis , glioma , protein kinase b , cancer research , ectopic expression , caspase , cell culture , tumor necrosis factor alpha , signal transduction , microbiology and biotechnology , kinase , inhibitor of apoptosis , biology , caspase 8 , protein kinase a , phosphorylation , mapk/erk pathway , chemistry , programmed cell death , immunology , biochemistry , genetics

Many tumor cells are resistant to Apo2L/TRAIL-induced apoptosis in the absence of inhibitors of protein synthesis. Apo2L/TRAIL, in addition to induction of apoptosis, may therefore also activate survival pathways.

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