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A Chronic Progressive Case of Enteroviral Limbic Encephalitis Associated with Autoantibody to Glutamate Receptor ε2
Author(s) -
Hideto Nakajima,
Mitsuaki Hosoya,
Yukitoshi Takahashi,
Kuniko Matsuyama,
Muneyoshi Tagami,
Simon Ishida,
Daisuke Furutama,
Masakazu Sugino,
Fumiharu Kimura,
Keiichi Shinoda,
Toshiaki Hanafusa
Publication year - 2007
Publication title -
european neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.573
H-Index - 77
eISSN - 1421-9913
pISSN - 0014-3022
DOI - 10.1159/000101289
Subject(s) - limbic encephalitis , autoantibody , glutamate receptor , encephalitis , medicine , neuroscience , immunology , pathology , receptor , psychology , virus , antibody
(mononuclear), pro-tein concentration 54 mg/dl and glucose 63 mg/dl. PCR for herpes simplex virus (HSV) DNA was negative. He was treated with acyclovir (30 mg/kg/day for 14 days) and betamethasone (16 mg/day for 7 days) based on the diagnosis of limbic encepha-litis. His symptoms and MRI abnormali-ties gradually disappeared by the second hospital month, and he was discharged without any sequelae. In November 1995, the patient again experienced a week of fever, headache and disorientation. At second admission, the patient was disoriented with memory im-pairment, including anterograde and ret-rograde amnesia. His Mini-Mental State Examination score was 17/30. FLAIR MRI again revealed hyperintense lesions in the bilateral hippocampal structures (f ig. 1B ). CSF examination showed 6 cells/mm

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