Heterogeneous Expression of Claudin-4 in Human Colorectal Cancer: Decreased Claudin-4 Expression at the Invasive Front Correlates Cancer Invasion and Metastasis | Zendy

Junya Ueda | Zendy; Shuho Semba | Zendy; Hideki Chiba | Zendy; Norimasa Sawada | Zendy; Yasushi Seo | Zendy; Masato Kasuga | Zendy; Hiroshi Yokozaki | Zendy

Open Access

Heterogeneous Expression of Claudin-4 in Human Colorectal Cancer: Decreased Claudin-4 Expression at the Invasive Front Correlates Cancer Invasion and Metastasis

Author(s) -

Junya Ueda,

Shuho Semba,

Hideki Chiba,

Norimasa Sawada,

Yasushi Seo,

Masato Kasuga,

Hiroshi Yokozaki

Publication year - 2007

Publication title -

pathobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.941

H-Index - 53

eISSN - 1423-0291

pISSN - 1015-2008

DOI - 10.1159/000101049

Subject(s) - claudin , gene knockdown , metastasis , colorectal cancer , small interfering rna , cancer research , tight junction , downregulation and upregulation , immunohistochemistry , cancer , medicine , biology , transfection , cell culture , pathology , microbiology and biotechnology , gene , biochemistry , genetics

Claudin-4 plays a key role in constructing the tight junction (TJ), and altered claudin-4 expression has been documented in various human malignancies; however, little is known about the biological significance of claudin-4 in colorectal cancers (CRCs). The aim of this study is to investigate the significance of claudin-4 expression in CRC and its association with clinicopathological factors.

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