Clinical Effects of Treatment for Hypogonadism in Male Adolescents with Prader-Labhart-Willi Syndrome | Zendy

Urs Eiholzer | Zendy; Jürgen Grieser | Zendy; Michael Schlumpf | Zendy; Dagmar l’Allemand | Zendy

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Clinical Effects of Treatment for Hypogonadism in Male Adolescents with Prader-Labhart-Willi Syndrome

Author(s) -

Urs Eiholzer,

Jürgen Grieser,

Michael Schlumpf,

Dagmar l’Allemand

Publication year - 2007

Publication title -

hormone research in paediatrics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.816

H-Index - 89

eISSN - 1663-2826

pISSN - 1663-2818

DOI - 10.1159/000100925

Subject(s) - virilization , endocrinology , medicine , testosterone (patch) , lean body mass , human chorionic gonadotropin , gonadotropin , hormone , androgen , body weight

In boys with Prader-Labhart-Willi syndrome (PWS), hypogonadism causes pubertal arrest and reduces pubertal muscle growth. Formerly, it was assumed that therapy with gonadal hormones accentuates behaviour abnormalities in PWS. Our aim was to assess the clinical effects of human chorionic gonadotropin (hCG) therapy on pubertal development, muscle mass and behaviour in adolescents with PWS.

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