Lactone Ring of Pectenotoxins: a Key Factor for their Activity on Cytoskeletal Dynamics | Zendy

Isabel R. Ares | Zendy; M. Carmen Louzao | Zendy; Begoña Espiña | Zendy; Mercedes R. Vieytes | Zendy; Christopher O. Miles | Zendy; Takeshi Yasumoto | Zendy; Luís M. Botana | Zendy

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Lactone Ring of Pectenotoxins: a Key Factor for their Activity on Cytoskeletal Dynamics

Author(s) -

Isabel R. Ares,

M. Carmen Louzao,

Begoña Espiña,

Mercedes R. Vieytes,

Christopher O. Miles,

Takeshi Yasumoto,

Luís M. Botana

Publication year - 2007

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000100647

Subject(s) - cytoskeleton , phalloidin , actin , actin cytoskeleton , biology , microbiology and biotechnology , confocal microscopy , fluorescence microscope , confocal , biochemistry , chemistry , fluorescence , cell , physics , geometry , mathematics , quantum mechanics

Pectenotoxins are a group of natural products from marine origin that can accumulate in shellfish and intoxicate humans. Recently, novel homologues such as pectenotoxin-11 (PTX-11) and pectenotoxin-2 seco acid (PTX-2SA) have been identified. Their toxic potential towards experimental animals has been evaluated however their interaction with cellular systems is almost unknown. This is the first report showing (i) the biological activity of PTX-11 and PTX-2SA on actin cytoskeleton and morphology of living cells and (ii) the structure- activity relationship for this family of toxic compounds.

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