Bmp7 Regulates Germ Cell Proliferation in Mouse Fetal Gonads | Zendy

Andrea J. Ross | Zendy; Steven C. Munger | Zendy; Blanche Capel | Zendy

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<i>Bmp7</i> Regulates Germ Cell Proliferation in Mouse Fetal Gonads

Author(s) -

Andrea J. Ross,

Steven C. Munger,

Blanche Capel

Publication year - 2007

Publication title -

sexual development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.528

H-Index - 44

eISSN - 1661-5433

pISSN - 1661-5425

DOI - 10.1159/000100034

Subject(s) - biology , gonad , germ cell , germ line development , microbiology and biotechnology , embryonic stem cell , bone morphogenetic protein , germ plasm , embryo , development of the gonads , cell growth , bone morphogenetic protein 7 , embryogenesis , endocrinology , medicine , genetics , gene

Relatively little is known regarding the signals that regulate the proliferation and sex-specific development of germ cells during mammalian fetal gonad differentiation. Members of the bone morphogenetic protein (BMP) family have been identified as key regulators of germ cells in the Drosophila gonad. Here we show that in mice Bmp7 is expressed in gonads of both sexes and is required for germ cell proliferation during a narrow window of development between 10.5-11.5 days post coitum (dpc). The proliferation defect is more severe in male than in female embryos suggesting that there are sexually dimorphic compensatory pathways. BMP signaling appears to be an evolutionarily conserved pathway regulating embryonic germ cell proliferation in vertebrate and invertebrate species.

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