Cell Surface Fucosylation Does Not Affect Development of Colon Tumors in Mice with Germline Smad3 Mutation | Zendy

Steven E. Domino | Zendy; David Karnak | Zendy; Elizabeth A. Hurd | Zendy

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Cell Surface Fucosylation Does Not Affect Development of Colon Tumors in Mice with Germline Smad3 Mutation

Author(s) -

Steven E. Domino,

David Karnak,

Elizabeth A. Hurd

Publication year - 2007

Publication title -

tumor biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.055

H-Index - 84

eISSN - 1423-0380

pISSN - 1010-4283

DOI - 10.1159/000099153

Subject(s) - fucosylation , fucosyltransferase , biology , cancer research , colorectal cancer , germline mutation , microbiology and biotechnology , mutation , pathology , gene , cancer , medicine , glycan , glycoprotein , genetics

Neoplasia-related alterations in cell surface alpha(1,2)fucosylated glycans have been reported in multiple tumors including colon, pancreas, endometrium, cervix, bladder, lung and choriocarcinoma. Spontaneous colorectal tumors from mice with a germline null mutation of transforming growth factor-beta signaling gene Smad3 (Madh3) were tested for alpha(1,2)fucosylated glycan expression.

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