Inhibition of the Na+-H+ Exchanger Isoform-1 and the Extracellular Signal-Regulated Kinase Induces Apoptosis: a Time Course of Events | Zendy

Diamantis G. Konstantinidis | Zendy; George Koliakos | Zendy; Katerina Vafia | Zendy; Panagiotis Liakos | Zendy; Christos Bantekas | Zendy; Varvara Trachana | Zendy; Martha Kaloyianni | Zendy

Open Access

Inhibition of the Na⁺-H⁺ Exchanger Isoform-1 and the Extracellular Signal-Regulated Kinase Induces Apoptosis: a Time Course of Events

Author(s) -

Diamantis G. Konstantinidis,

George Koliakos,

Katerina Vafia,

Panagiotis Liakos,

Christos Bantekas,

Varvara Trachana,

Martha Kaloyianni

Publication year - 2006

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000097668

Subject(s) - extracellular , apoptosis , signal transduction , gene isoform , chemistry , kinase , extracellular signal regulated kinases , sodium–hydrogen antiporter , microbiology and biotechnology , protein kinase a , biology , biochemistry , gene , organic chemistry , sodium

The present study attempts to shed light on the role and the relative position of the Na(+)/H(+) exchanger isoform 1 (NHE1) and the extracellular signal-regulated kinase (ERK) in HEp-2 cell signaling pathways concerning a diverse range of cellular functions such as regulation of intracellular pH (pHi), DNA synthesis, production of reactive oxygen species (ROS) and apoptosis.

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