High Glucose Up-Regulates ENaC and SGK1 Expression in HCD-Cells | Zendy

Claire E. Hills | Zendy; Rosemary Bland | Zendy; Jeanette Bennett | Zendy; Pierre Ronco | Zendy; Paul E. Squires | Zendy

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High Glucose Up-Regulates ENaC and SGK1 Expression in HCD-Cells

Author(s) -

Claire E. Hills,

Rosemary Bland,

Jeanette Bennett,

Pierre Ronco,

Paul E. Squires

Publication year - 2006

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000097611

Subject(s) - epithelial sodium channel , sgk1 , endocrinology , medicine , diabetic nephropathy , ionomycin , renal sodium reabsorption , western blot , chemistry , diabetes mellitus , sodium , kidney , reabsorption , glucocorticoid , biochemistry , calcium , organic chemistry , gene

Diabetic nephropathy is associated with progressive renal damage, leading to impaired function and end-stage renal failure. Secondary hypertension stems from a deranged ability of cells within the kidney to resolve and appropriately regulate sodium resorption in response to hyperglycaemia. However, the mechanisms by which glucose alters sodium re-uptake have not been fully characterised.

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