Role of Cytokines in Allergic Airway Inflammation | Zendy

Hiroshi Nakajima | Zendy; Kiyoshi Takatsu | Zendy

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Role of Cytokines in Allergic Airway Inflammation

Author(s) -

Hiroshi Nakajima,

Kiyoshi Takatsu

Publication year - 2006

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000097357

Subject(s) - thymic stromal lymphopoietin , immunology , inflammation , asthma , allergic inflammation , medicine , pathogenesis , proinflammatory cytokine , interleukin 13 , interleukin 5 , interleukin , interleukin 4 , innate lymphoid cell , interleukin 33 , cytokine , immune system , acquired immune system

Asthma is characterized by intense infiltration of eosinophils and CD4+ T cells into the submucosal tissue of airways. Accumulating evidence indicates that T helper type 2 cell-derived cytokines such as interleukin (IL)-4, IL-5 and IL-13 play critical roles in orchestrating and amplifying allergic inflammation in asthma. In addition, it has been suggested that newly identified cytokines including thymic stromal lymphopoietin, IL-25 and IL-33 are involved in the induction of allergic inflammation in asthma. In this review, we discuss the role of individual cytokines in the pathogenesis of asthma.

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