Tumor Necrosis Factor Alpha Differentially Regulates Beta-Endorphin Concentrations and Proopiomelanocortin RNA in the Anterior and Neurointermediate Pituitary in vivo | Zendy

Paola Sacerdote | Zendy; A.T. Brini | Zendy; Luisa Locatelli | Zendy; Jelena Raduloviç | Zendy; Alberto E. Panerai | Zendy

Open Access

Tumor Necrosis Factor Alpha Differentially Regulates Beta-Endorphin Concentrations and Proopiomelanocortin RNA in the Anterior and Neurointermediate Pituitary in vivo

Author(s) -

Paola Sacerdote,

A.T. Brini,

Luisa Locatelli,

Jelena Raduloviç,

Alberto E. Panerai

Publication year - 1994

Publication title -

neuroimmunomodulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.635

H-Index - 65

eISSN - 1423-0216

pISSN - 1021-7401

DOI - 10.1159/000097188

Subject(s) - proopiomelanocortin , medicine , endocrinology , anterior pituitary , beta endorphin , tumor necrosis factor alpha , cytokine , pituitary gland , in vivo , chemistry , biology , hypothalamus , hormone , microbiology and biotechnology

We analyzed the effect of tumor necrosis factor alpha (TNF-alpha) on beta-endorphin concentrations and proopiomelanocortin mRNA in the rat anterior and neurointermediate pituitaries. The intraperitoneal injection of 5 micrograms/kg TNF-alpha decreases beta-endorphin in neurointermediate pituicytes 4, 8 and 24 h after the treatment without affecting proopiomelanocortin (POMC) RNA. In contrast, in the anterior pituitary 4 h after the injection of the cytokine, POMC RNA was decreased while the peptide content was increased. These effects can be relevant to the modulation of the pituitary-adrenal axis and immune responses in conditions, such as infections, in which TNF levels are increased.

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