Involvement of Homeobox Genes in Mammalian Sexual Development | Zendy

Terje Svingen | Zendy; Peter Koopman | Zendy

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Involvement of Homeobox Genes in Mammalian Sexual Development

Author(s) -

Terje Svingen,

Peter Koopman

Publication year - 2006

Publication title -

sexual development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.528

H-Index - 44

eISSN - 1661-5433

pISSN - 1661-5425

DOI - 10.1159/000096235

Subject(s) - homeobox , biology , organogenesis , homeobox protein nkx 2.5 , morphogenesis , homeobox a1 , testis determining factor , sexual differentiation , primordium , gonad , emx2 , genetics , gene , embryo , dlx5 , microbiology and biotechnology , gonadal ridge , embryogenesis , anatomy , gene expression , y chromosome

In eutherian mammals, sexual development hinges on the differentiation of the gonadal primordia into either testes or ovaries, in turn determined by the activity of the Y-linked gene Sry. Organogenesis of the gonads requires input from a complex network of morphogenetic signals, many of which are still uncharacterised. Homeobox genes are known to play important roles in embryo morphogenesis and organogenesis in a number of systems. Here, we review current data relating to possible roles of the extended homeobox gene family on gonad development, sex-specific morphogenesis and gametogenesis, and speculate that these genes may play a broader role in these processes than is currently suspected.

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