Endoglin Modulation of TGF-ß1-Induced Collagen Synthesis is Dependent on ERK1/2 MAPK Activation | Zendy

Alicia RodríguezBarbero | Zendy; Juana Obreo | Zendy; Patricia Álvarez-Muñoz | Zendy; Atanasio Pandiella | Zendy; Carmelo Bernabéu | Zendy; José M. LópezNovoa | Zendy

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Endoglin Modulation of TGF-ß1-Induced Collagen Synthesis is Dependent on ERK1/2 MAPK Activation

Author(s) -

Alicia RodríguezBarbero,

Juana Obreo,

Patricia Álvarez-Muñoz,

Atanasio Pandiella,

Carmelo Bernabéu,

José M. LópezNovoa

Publication year - 2006

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000095181

Subject(s) - endoglin , extracellular matrix , transforming growth factor , mapk/erk pathway , transfection , chemistry , microbiology and biotechnology , myocyte , transforming growth factor beta , type i collagen , western blot , p38 mitogen activated protein kinases , extracellular , signal transduction , biology , endocrinology , biochemistry , gene , stem cell , cd34

Transforming growth factor-beta1 (TGF-beta1) plays a pivotal role in the extracellular matrix accumulation observed in fibrotic diseases. Endoglin is an important component of the TGF-beta receptor complex highly expressed in tissues undergoing fibrotic processes. Endoglin expression regulates the effect of TGF-beta on extracellular matrix synthesis. The purpose of our study has been to understand the molecular mechanism by which endoglin exerts its effects on fibrosis and the possible role of MAP kinases in these effects.

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