Patterns of Frontal Lobe Atrophy in Frontotemporal Dementia: A Volumetric MRI Study | Zendy

Richard Perry | Zendy; Andrew Graham | Zendy; Guy Williams | Zendy; Howard J. Rosen | Zendy; Sharon Erzinçlioğlu | Zendy; Mike Weiner | Zendy; Bruce L. Miller | Zendy; John R. Hodges | Zendy

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Patterns of Frontal Lobe Atrophy in Frontotemporal Dementia: A Volumetric MRI Study

Author(s) -

Richard Perry,

Andrew Graham,

Guy Williams,

Howard J. Rosen,

Sharon Erzinçlioğlu,

Mike Weiner,

Bruce L. Miller,

John R. Hodges

Publication year - 2006

Publication title -

dementia and geriatric cognitive disorders

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.026

H-Index - 110

eISSN - 1421-9824

pISSN - 1420-8008

DOI - 10.1159/000095128

Subject(s) - frontal lobe , frontotemporal dementia , atrophy , psychology , orbitofrontal cortex , insula , dorsolateral prefrontal cortex , temporal lobe , dementia , audiology , prefrontal cortex , neuroscience , medicine , epilepsy , cognition , disease

Frontotemporal dementia (FTD), the second commonest degenerative cause of dementia under the age of 65, often presents with striking changes in behaviour and personality in association with frontal lobe atrophy. Based on the behavioural changes observed in FTD, it is commonly assumed that the orbitofrontal cortex is the earliest and most severely affected frontal sub-region. However, evidence to support this assumption has to date been largely lacking.

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