Targeting Pericytes Diminishes Neovascularization in Orthotopic Uveal Melanoma in Nerve/Glial Antigen 2 Proteoglycan Knockout Mouse | Zendy

Uğur Özerdem | Zendy

Open Access

Targeting Pericytes Diminishes Neovascularization in Orthotopic Uveal Melanoma in Nerve/Glial Antigen 2 Proteoglycan Knockout Mouse

Author(s) -

Uğur Özerdem

Publication year - 2006

Publication title -

ophthalmic research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.893

H-Index - 54

eISSN - 1423-0259

pISSN - 0030-3747

DOI - 10.1159/000094833

Subject(s) - pericyte , melanoma , proteoglycan , neovascularization , knockout mouse , pathology , cancer research , uvea , corneal neovascularization , chemistry , biology , angiogenesis , microbiology and biotechnology , extracellular matrix , medicine , endothelial stem cell , receptor , in vitro , biochemistry

In this investigation, we explored whether knockout of nerve/glial antigen 2 (NG2), a pericyte component, inhibited neovascularization and growth of uveal melanoma xenografts. For this, we used multichannel laser scanning confocal microscopy and quantitative image analysis. Orthotopic human uveal melanoma (OCM-1A) xenografts were induced in NG2 knockout and wild-type mice, which were immunosuppressed with cyclosporin A. Inhibition of pericytes through NG2 proteoglycan decreased neovascularization and tumor end volume, rendering pericytes and NG2 proteoglycan potential cellular and molecular therapeutic targets in uveal melanoma.

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