Nerve Growth Factor, Neural Stem Cells and Alzheimer’s Disease | Zendy

Klaus Heese | Zendy; Jin Wei Low | Zendy; Noriko Inoue | Zendy

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Nerve Growth Factor, Neural Stem Cells and Alzheimer’s Disease

Author(s) -

Klaus Heese,

Jin Wei Low,

Noriko Inoue

Publication year - 2006

Publication title -

neurosignals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.755

H-Index - 67

eISSN - 1424-8638

pISSN - 1424-862X

DOI - 10.1159/000094383

Subject(s) - nerve growth factor , neuroscience , neurotrophin , neural stem cell , neurotrophic factors , stem cell , alzheimer's disease , disease , nerve cells , biology , psychology , medicine , microbiology and biotechnology , receptor

The protein family of the neurotrophins (NTs) comprises structurally and functionally related molecules such as nerve growth factor (NGF) which influences the proliferation, differentiation, survival and death of neuronal cells. In addition to their established functions for cell survival, NTs also mediate higher brain activities such as learning and memory. Changes in NT expression levels have thus been implicated in neurological diseases such as Alzheimer's disease (AD), an age-related neurodegenerative disorder that is characterized by progressive loss of memory and deterioration of higher cognitive functions. The present review provides an overview of the functional role of NGF in neural stem cells and AD while pointing to a potential application of this peptide for the treatment of AD.

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