Genesis of Prolactinomas: Studies Using Estrogen-Treated Animals | Zendy

Dipak K. Sarkar | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Genesis of Prolactinomas: Studies Using Estrogen-Treated Animals

Author(s) -

Dipak K. Sarkar

Publication year - 2006

Publication title -

karger ebooks

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.625

H-Index - 36

ISSN - 0301-3073

DOI - 10.1159/000094307

Subject(s) - prolactinoma , endocrinology , medicine , prolactin cell , prolactin , transforming growth factor beta , receptor , cell growth , biology , estrogen , signal transduction , acromegaly , cancer research , transforming growth factor , microbiology and biotechnology , hormone , growth hormone , biochemistry

Prolactin-secreting adenomas (prolactinomas) are the most prevalent form of pituitary tumors in humans. Our knowledge of the formation of these tumors is limited. Experimental work in animal has uncovered that estradiol exposure leads to prolactinoma formation via orchestrated events involving dopamine D2 receptors, transforming growth factor-beta(TGF-beta) isoforms and their receptors, as well as factors secondary to TGF-beta action. Additionally, these studies determined that TGF-beta and b-FGF interact to facilitate the communication between lactotropes and folliculo-stellate cells that is necessary for the mitogenic action of estradiol. The downstream signaling that governs lactotropic cell proliferation involves activation of the MAP kinase p44/42-dependent pathway.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research