The Sodium Channel of Human Excitable Cells is a Target for Gambierol | Zendy

M. Carmen Louzao | Zendy; Eva Cagide | Zendy; Mercedes R. Vieytes | Zendy; Makoto Sasaki | Zendy; Haruhiko Fuwa | Zendy; Takeshi Yasumoto | Zendy; Luís M. Botana | Zendy

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The Sodium Channel of Human Excitable Cells is a Target for Gambierol

Author(s) -

M. Carmen Louzao,

Eva Cagide,

Mercedes R. Vieytes,

Makoto Sasaki,

Haruhiko Fuwa,

Takeshi Yasumoto,

Luís M. Botana

Publication year - 2006

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000094138

Subject(s) - veratridine , ciguatoxin , chemistry , depolarization , sodium channel , marine toxin , calcium , fura 2 , aconitine , intracellular , pharmacology , sodium , agonist , membrane potential , biophysics , stereochemistry , cytosol , biochemistry , toxin , receptor , biology , chromatography , organic chemistry , fishery , fish <actinopterygii> , enzyme

Gambierol is a polycyclic ether toxin with the same biogenetic origin as ciguatoxins. Gambierol has been associated with neurological symptoms in humans even though its mechanism of action has not been fully characterized.

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