Mechanisms of Neutrophil Transmigration Across Renal Proximal Tubular HK-2 Cells | Zendy

Klaudija Bijuklic | Zendy; Daniel H. Sturn | Zendy; Paul Jennings | Zendy; Jordan Kountchev | Zendy; Walter Pfaller | Zendy; Christian J. Wiedermann | Zendy; Josef R. Patsch | Zendy; Michael Joannidis | Zendy

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Mechanisms of Neutrophil Transmigration Across Renal Proximal Tubular HK-2 Cells

Author(s) -

Klaudija Bijuklic,

Daniel H. Sturn,

Paul Jennings,

Jordan Kountchev,

Walter Pfaller,

Christian J. Wiedermann,

Josef R. Patsch,

Michael Joannidis

Publication year - 2006

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000094128

Subject(s) - cd47 , antibody , chemistry , tumor necrosis factor alpha , cytokine , immunofluorescence , microbiology and biotechnology , cell adhesion molecule , inflammation , biology , immunology

Adhesion of intratubular leukocytes to proximal tubules in biopsies of patients with rapidly progressive glomerulonephritis and the appearance of leukocytes in the urine in interstitial nephritis suggest interactions between leukocytes and tubular epithelia in renal diseases. The aim of this study was to investigate the effect of cytokines and endotoxin on leukocyte migration through proximal tubular epithelial cells and also to determine the role of the transmembrane adhesion molecules ICAM-1 and CD47 in this process.

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