Apolipoprotein E ε4 Allele Is Unrelated to Cognitive or Functional Decline in Alzheimer’s Disease: Retrospective and Prospective Analysis | Zendy

Timothy Kleiman | Zendy; Kristina Zdanys | Zendy; Benjamin Black | Zendy; Tracy Rightmer | Zendy; Monique Grey | Zendy; Katherine S. Garman | Zendy; Martha G. MacAvoy | Zendy; Joel Gelernter | Zendy; Christopher van Dyck | Zendy

Open Access

Apolipoprotein E ε4 Allele Is Unrelated to Cognitive or Functional Decline in Alzheimer’s Disease: Retrospective and Prospective Analysis

Author(s) -

Timothy Kleiman,

Kristina Zdanys,

Benjamin Black,

Tracy Rightmer,

Monique Grey,

Katherine S. Garman,

Martha G. MacAvoy,

Joel Gelernter,

Christopher van Dyck

Publication year - 2006

Publication title -

dementia and geriatric cognitive disorders

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.026

H-Index - 110

eISSN - 1421-9824

pISSN - 1420-8008

DOI - 10.1159/000093316

Subject(s) - alzheimer's disease , dementia , apolipoprotein e , disease , cognitive decline , degenerative disease , cognition , psychology , allele , medicine , psychiatry , genetics , biology , gene

The apolipoprotein E (ApoE) epsilon4 allele is a well-documented genetic risk factor for Alzheimer's disease (AD). Its role, if any, in the progression of cognitive and functional impairment in AD has been the subject of discrepant reports in the literature. This study aimed to determine whether ApoE epsilon4 dose is related to the progression of cognitive and functional decline in AD patients by combined retrospective and prospective analyses.

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