Regulation of TRP Channels by Phosphorylation | Zendy

Xiaoqiang Yao | Zendy; Hiu Yee Kwan | Zendy; Yü Huang | Zendy

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Regulation of TRP Channels by Phosphorylation

Author(s) -

Xiaoqiang Yao,

Hiu Yee Kwan,

Yü Huang

Publication year - 2005

Publication title -

neurosignals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.755

H-Index - 67

eISSN - 1424-8638

pISSN - 1424-862X

DOI - 10.1159/000093042

Subject(s) - transient receptor potential channel , phosphorylation , dephosphorylation , ion channel , microbiology and biotechnology , osmotic concentration , protein phosphorylation , serine , kinase , chemistry , biology , neuroscience , receptor , biochemistry , protein kinase a , phosphatase

The transient receptor potential (TRP) channels are a group of Ca2+-permeable cation channels (except TRPM4 and TRPM5) that function as cellular sensors of various internal and external stimuli. Most of these channels are expressed in the nervous system and they play a key role in sensory physiology. They may respond to temperature, pressure, inflammatory agents, pain, osmolarity, taste and many other stimuli. Recent development indicates that the activity of these channels is regulated by protein phosphorylation and dephosphorylation of serine, threonine, and tyrosine residues. In this review, we present a comprehensive summary of the literature regarding the TRP channel regulation by different protein kinases.

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