Modulation of Dendritic Cells for Tolerance Induction* | Zendy

Holger Hackstein | Zendy

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Modulation of Dendritic Cells for Tolerance Induction*

Author(s) -

Holger Hackstein

Publication year - 2006

Publication title -

transfusion medicine and hemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 39

eISSN - 1660-3818

pISSN - 1660-3796

DOI - 10.1159/000091105

Subject(s) - alloimmunity , immune modulation , autoimmunity , immunology , immune system , dendritic cell , immune tolerance , acquired immune system , antigen , medicine , modulation (music) , philosophy , aesthetics

Dendritic cells (DC) play a critical role as initiators and modulators of adaptive immune responses. There is increasing evidence that DC have potent abilities to tolerize and delete T cells in an antigen-specific manner. Immature or semi-mature DC generated in the laboratory can suppress autoimmunity or alloimmunity. With emphasis on the pharmacological modulation of DC, we herewith provide an update on current strategies and concepts to promote the tolerogenic potential of DC for therapy of transplant rejection and autoimmune disease.

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