Osmotic Regulation of MG-132-induced MAP-kinase Phosphatase MKP-1 Expression in H4IIE Rat Hepatoma Cells
Author(s) -
Mohammad Reza LornejadSchäfer,
Christine Schäfer,
Lisa Richter,
Tilman Grune,
Dieter Häussinger,
Freimut Schliess
Publication year - 2005
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000089845
Subject(s) - phosphatase , microbiology and biotechnology , kinase , osmotic shock , biology , chemistry , biochemistry , phosphorylation , gene
Proteasome inhibitors such as MG-132 are considered as potential therapeutical tools in different clinical settings. The dual specificity MAP-kinase phosphatase MKP-1 plays a role in balancing signals mediating cell death or survival. Here the effect of cell hydration on MG-132-induced MKP-1 expression was investigated in H4IIE rat hepatoma cells.
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