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Proteasome inhibitors such as MG-132 are considered as potential therapeutical tools in different clinical settings. The dual specificity MAP-kinase phosphatase MKP-1 plays a role in balancing signals mediating cell death or survival. Here the effect of cell hydration on MG-132-induced MKP-1 expression was investigated in H4IIE rat hepatoma cells.

Osmotic Regulation of MG-132-induced MAP-kinase Phosphatase MKP-1 Expression in H4IIE Rat Hepatoma Cells