Choline Produces Cytoprotective Effects Against Ischemic Myocardial Injuries: Evidence for the Role of Cardiac M3 Subtype Muscarinic Acetylcholine Receptors | Zendy

Baofeng Yang | Zendy; Huixian Lin | Zendy; Chaoqian Xu | Zendy; Yan Liu | Zendy; Huizhen Wang | Zendy; Ho Jae Han | Zendy; Zhiguo Wang | Zendy

Open Access

Choline Produces Cytoprotective Effects Against Ischemic Myocardial Injuries: Evidence for the Role of Cardiac M<sub>3</sub> Subtype Muscarinic Acetylcholine Receptors

Author(s) -

Baofeng Yang,

Huixian Lin,

Chaoqian Xu,

Yan Liu,

Huizhen Wang,

Ho Jae Han,

Zhiguo Wang

Publication year - 2005

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000089842

Subject(s) - muscarinic acetylcholine receptor , cytoprotection , medicine , cardiac function curve , acetylcholine , oxidative stress , ischemia , pharmacology , endocrinology , receptor , heart failure

Accumulating evidence indicates the presence of functional M3 subtype of acetylcholine muscarinic receptors (M(3)-mAChR), in addition to the well-recognized M(2)-mAChR, in the heart of various species including man. However, the pathophysiological role of the cardiac M(3)-mAChR remain undefined. This study was designed to explore the possible role of M(3)-mAChR in cytoprotection of myocardial infarction and several related signaling pathways as potential mechanisms.

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