Vascular Calcification in Patients with Chronic Kidney Disease | Zendy

Santo Dellegrottaglie | Zendy; Javier Sanz | Zendy; Sanjay Rajagopalan | Zendy

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Vascular Calcification in Patients with Chronic Kidney Disease

Author(s) -

Santo Dellegrottaglie,

Javier Sanz,

Sanjay Rajagopalan

Publication year - 2005

Publication title -

blood purification

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.686

H-Index - 57

eISSN - 1421-9735

pISSN - 0253-5068

DOI - 10.1159/000089438

Subject(s) - kidney disease , medicine , pathophysiology , disease , calcification , intensive care medicine , vascular disease , population , cardiology , pathology , environmental health

Chronic kidney disease (CKD) represents an extremely common condition, and cardiovascular diseases are frequently reported in this patient population. Traditional risk factors are not accurate prognostic predictors in CKD patients, and new potential markers to predict the cardiovascular involvement in uremic patients need to be identified. Vascular calcification (VC) represents a hallmark of the atherosclerotic process in CKD. This review summarizes the processes responsible for VC (particularly focusing on the mechanisms operative in the presence of renal dysfunction), discusses the utility of computer tomography modalities in the detection of VC in patients with CKD, and reports the potential role of VC as pathophysiological link between kidney disease and cardiovascular events.

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