Blood Vessels and the Aging Kidney | Zendy

David A. Long | Zendy; Wei Mu | Zendy; Karen Price | Zendy; Richard J. Johnson | Zendy

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Blood Vessels and the Aging Kidney

Author(s) -

David A. Long,

Wei Mu,

Karen Price,

Richard J. Johnson

Publication year - 2005

Publication title -

nephron experimental nephrology

Language(s) - English

Resource type - Journals

ISSN - 1660-2129

DOI - 10.1159/000087146

Subject(s) - kidney , renal blood flow , renal function , angiogenesis , medicine , nitric oxide , endocrinology , angiotensin ii , renal circulation , hemodynamics , vascular endothelial growth factor , blood pressure , vegf receptors

Aging is associated with a degenerative effect on many organs including the kidney. Blood vessels play a key role in the progression of renal damage in aging, with reductions in glomerular filtration rate and renal blood flow. Therefore, there is considerable interest in the haemodynamic and molecular mechanisms that may be responsible for alterations in the vascular system in aging. In this review, we will describe the evidence that aging is accompanied by alterations in vascular tone and angiogenesis alongside renal damage. The contributions of mediators such as nitric oxide, angiotensin II and vascular endothelial growth factor will also be discussed.

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