Linkage Disequilibrium Inflates Type I Error Rates in Multipoint Linkage Analysis when Parental Genotypes Are Missing | Zendy

Abee L. Boyles | Zendy; William K. Scott | Zendy; Eden R. Martin | Zendy; Silke Schmidt | Zendy; YiJu Li | Zendy; Allison E. AshleyKoch | Zendy; Meredyth P. Bass | Zendy; Michael A. Schmidt | Zendy; Margaret A. PericakVance | Zendy; Marcy C. Speer | Zendy; Elizabeth R. Hauser | Zendy

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Linkage Disequilibrium Inflates Type I Error Rates in Multipoint Linkage Analysis when Parental Genotypes Are Missing

Author(s) -

Abee L. Boyles,

William K. Scott,

Eden R. Martin,

Silke Schmidt,

YiJu Li,

Allison E. AshleyKoch,

Meredyth P. Bass,

Michael A. Schmidt,

Margaret A. PericakVance,

Marcy C. Speer,

Elizabeth R. Hauser

Publication year - 2005

Publication title -

human heredity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.423

H-Index - 62

eISSN - 1423-0062

pISSN - 0001-5652

DOI - 10.1159/000087122

Subject(s) - linkage disequilibrium , genetics , linkage (software) , genetic linkage , biology , allele frequency , minor allele frequency , population , haplotype , genotype , allele , gene , demography , sociology

Describe the inflation in nonparametric multipoint LOD scores due to inter-marker linkage disequilibrium (LD) across many markers with varied allele frequencies.

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