Expression of Inducible Nitric Oxide Synthase Is Significantly Correlated with Expression of Vascular Endothelial Growth Factor and Dendritic Cell Infiltration in Patients with Advanced Gastric Carcinoma | Zendy

Kenichi Yamaguchi | Zendy; Hiroaki Saito | Zendy; Shotaro Oro | Zendy; Shigeru Tatebe | Zendy; Masahide Ikeguchi | Zendy; Shunichi Tsujitani | Zendy

Open Access

Expression of Inducible Nitric Oxide Synthase Is Significantly Correlated with Expression of Vascular Endothelial Growth Factor and Dendritic Cell Infiltration in Patients with Advanced Gastric Carcinoma

Author(s) -

Kenichi Yamaguchi,

Hiroaki Saito,

Shotaro Oro,

Shigeru Tatebe,

Masahide Ikeguchi,

Shunichi Tsujitani

Publication year - 2005

Publication title -

oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.987

H-Index - 98

eISSN - 1423-0232

pISSN - 0030-2414

DOI - 10.1159/000086990

Subject(s) - angiogenesis , nitric oxide synthase , vascular endothelial growth factor , nitric oxide , immune system , immunohistochemistry , neovascularization , citrulline , medicine , pathology , cancer research , biology , immunology , arginine , vegf receptors , biochemistry , amino acid

Nitric oxide (NO) is a product of L-arginine to L-citrulline conversion by nitric oxide synthase (NOS). The inducible form of NOS (iNOS) is one of three classes of NOS and the strongest producer of NO. It has been reported that NO correlates with angiogenesis and immune responses in some types of cancer, however, the correlations between iNOS expression, angiogenesis, and immune responses are still unclear in gastric carcinoma.

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