S-Adenosylhomocysteine Metabolism in Different Cell Lines: Effect of Hypoxia and Cell Density | Zendy

Marina Hermes | Zendy; Sandra von Hippel | Zendy; Hartmut Oßwald | Zendy; Doris Kloor | Zendy

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S-Adenosylhomocysteine Metabolism in Different Cell Lines: Effect of Hypoxia and Cell Density

Author(s) -

Marina Hermes,

Sandra von Hippel,

Hartmut Oßwald,

Doris Kloor

Publication year - 2005

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000086410

Subject(s) - hela , hek 293 cells , hypoxia (environmental) , cell culture , metabolite , transmethylation , chemistry , cell , metabolism , cell growth , microbiology and biotechnology , methylation , biochemistry , biology , oxygen , gene , organic chemistry , genetics

The methylation potential (MP) is defined as the ratio of S-adenosylmethionine (AdoMet) to S-adenosylhomocysteine (AdoHcy). It was shown recently that hypoxia increases AdoMet/AdoHcy ratio in HepG2 cells (Hermes et al., Exp Cell Res 294: 325-334, 2004). In the present study, we compared AdoMet/AdoHcy ratio and energy metabolism in HepG2, HEK-293, HeLa, MCF-7 and SK-HEP-1 cell lines under normoxia and hypoxia.

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