Rat Brown Adipose Tissue Thermogenic Features are Altered During Mid-Pregnancy | Zendy

Marga Frontera | Zendy; Esperanza Pujol | Zendy; Sergio Rodrı́guez-Cuenca | Zendy; Antoni Català-Niell | Zendy; Pilar Roca | Zendy; Francisco García-Palmer | Zendy; Magdalena Gianotti | Zendy

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Rat Brown Adipose Tissue Thermogenic Features are Altered During Mid-Pregnancy

Author(s) -

Marga Frontera,

Esperanza Pujol,

Sergio Rodrı́guez-Cuenca,

Antoni Català-Niell,

Pilar Roca,

Francisco García-Palmer,

Magdalena Gianotti

Publication year - 2005

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000086407

Subject(s) - brown adipose tissue , adipose tissue , thermogenesis , endocrinology , pregnancy , medicine , biology , microbiology and biotechnology , genetics

Brown adipose tissue (BAT) thermogenesis is inhibited during late-pregnancy and lactation in the rat. However, scarce information concerning BAT functionality during mid-pregnancy is available. The aim of this work was to investigate uncoupling proteins and leptin expression during placentation in rat BAT as well as other key parameters in the thermogenic function of the tissue. BAT mitochondrial content was found to be reduced 50% in 11 and 13 day pregnant rats as compared to nonpregnant controls, although uncoupling protein 1 (UCP1) content was not modified. Furthermore, UCP3 mRNA levels were found to be highly increased during this period. beta3-adrenergic receptor (beta3-AR) decreased expression resulted in a higher alpha2/beta3 ratio. Finally, leptin mRNA levels in BAT were found to be 3-fold up-regulated in pregnant animals. In conclusion, we show the existence of profound changes in thermogenic features in BAT during gestational days 11 and 13, pointing to the importance of this tissue during mid-pregnancy.

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