Hypoxia-Inducible Factor-1α Is Involved in the Attenuation of Experimentally Induced Rat Glomerulonephritis | Zendy

Yoshihiro Kudo | Zendy; Yoshihiko Kakinuma | Zendy; Yasukiyo Mori | Zendy; Norihito Morimoto | Zendy; Takashi Karashima | Zendy; Mutsuo Furihata | Zendy; Takayuki Sato | Zendy; Taro Shuin | Zendy; Tetsuro Sugiura | Zendy

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Hypoxia-Inducible Factor-1α Is Involved in the Attenuation of Experimentally Induced Rat Glomerulonephritis

Author(s) -

Yoshihiro Kudo,

Yoshihiko Kakinuma,

Yasukiyo Mori,

Norihito Morimoto,

Takashi Karashima,

Mutsuo Furihata,

Takayuki Sato,

Taro Shuin,

Tetsuro Sugiura

Publication year - 2005

Publication title -

nephron experimental nephrology

Language(s) - English

Resource type - Journals

ISSN - 1660-2129

DOI - 10.1159/000084575

Subject(s) - hypoxia (environmental) , glomerulonephritis , medicine , endocrinology , chemistry , pathology , biology , kidney , oxygen , organic chemistry

Among various kidney disease models, there are few rat glomerulonephritis (GN) models that develop in a short time, and with mainly glomerular lesions. Hypoxia-inducible factor (HIF)-1alpha is a transcriptional factor that induces genes supporting cell survival, but the involvement of HIF-1alpha in attenuating the progression of GN remains to be elucidated. We developed a new model of rat GN by coadministration of angiotensin II (AII) with Habu snake venom (HV) and investigated whether HIF-1alpha is involved in renal protection.

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