Open AccessCellular Oxidative Processes in Relation to Renal Disease
Author(s) -
E. N. Wardle
Publication year - 2005
Publication title -
american journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 85
eISSN - 1421-9670
pISSN - 0250-8095
DOI - 10.1159/000083477
Subject(s) - oxidative stress , reactive oxygen species , medicine , nephrology , pathophysiology , signal transduction , kidney disease , disease , oxidative phosphorylation , kidney , microbiology and biotechnology , biology , biochemistry
This article summarizes the biochemical processes that produce reactive oxygen species (ROS) and other mediators that account for 'oxidative stress'. Formation of ROS in signal transduction cascades is illustrated from studies of kidney cell systems. The pathophysiological implications for the nephrologist are then reviewed.
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