Effect of a Matrix Metalloproteinase Activity and TNF-Alpha Converting Enzyme Inhibitor on Intra-Abdominal Adhesions | Zendy

Ursula Mirastschijski | Zendy; Kristina Åhsberg Johannesson | Zendy; Bengt Jeppsson | Zendy; Magnus S. Ågren | Zendy

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Effect of a Matrix Metalloproteinase Activity and TNF-Alpha Converting Enzyme Inhibitor on Intra-Abdominal Adhesions

Author(s) -

Ursula Mirastschijski,

Kristina Åhsberg Johannesson,

Bengt Jeppsson,

Magnus S. Ågren

Publication year - 2005

Publication title -

european surgical research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.658

H-Index - 46

eISSN - 1421-9921

pISSN - 0014-312X

DOI - 10.1159/000083150

Subject(s) - hydroxyproline , medicine , wound healing , adhesion , tumor necrosis factor alpha , matrix metalloproteinase , cell adhesion , necrosis , endocrinology , surgery , chemistry , organic chemistry

Formation of intra-abdominal adhesions depends, in part, on the activity of serine proteinases. Matrix metalloproteinases (MMP) are required for epithelialization of skin wounds but their involvement in mesothelialization of peritoneal wounds and in adhesion pathogenesis is not known. Early tumor necrosis factor-alpha (TNF-alpha) levels have been proposed to reflect propensity to adhesion formation.

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