Open AccessHypocapnia Induces Caspase-3 Activation and Increases Aβ Production
Author(s) -
Zhongcong Xie,
Robert D. Moir,
Donna Romano,
Giuseppina Tesco,
Dora M. Kovacs,
Rudolph E. Tanzi
Publication year - 2004
Publication title -
neurodegenerative diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.98
H-Index - 57
eISSN - 1660-2862
pISSN - 1660-2854
DOI - 10.1159/000076667
Subject(s) - hypocapnia , apoptosis , chemistry , presenilin , medicine , endocrinology , microbiology and biotechnology , biology , biochemistry , alzheimer's disease , hypercapnia , disease , respiratory system
At least half of all cases of early onset (<60) familial Alzheimer's disease (FAD) are caused by any of over 150 mutations in three genes: the amyloid precursor protein (APP), presenilin 1 (PS1), and presenilin 2 (PS2). Mutant forms of PS1 have been shown to sensitize cells to apoptotic cell death.
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