Neuronal Apoptosis in Neurodegenerative Diseases: From Basic Research to Clinical Application | Zendy

Pawel Kermer | Zendy; Jan Liman | Zendy; Jochen H. Weishaupt | Zendy; Mathias Bähr | Zendy

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Neuronal Apoptosis in Neurodegenerative Diseases: From Basic Research to Clinical Application

Author(s) -

Pawel Kermer,

Jan Liman,

Jochen H. Weishaupt,

Mathias Bähr

Publication year - 2004

Publication title -

neurodegenerative diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.98

H-Index - 57

eISSN - 1660-2862

pISSN - 1660-2854

DOI - 10.1159/000076665

Subject(s) - amyotrophic lateral sclerosis , neuroscience , disease , huntington's disease , medicine , parkinson's disease , apoptosis , pathology , psychology , biology , biochemistry

In recent years, the investigation of erroneous regulation of apoptotic mechanisms during acute and chronic injury of neuronal cells has gained increasing attention. Besides acute neuronal trauma and ischemia, chronic neurodegenerative diseases like Alzheimer's, Huntington's, Parkinson's and Lou-Gehrig's disease (amyotrophic lateral sclerosis) are of particular interest. The present article will provide an overview of basic apoptotic mechanisms, the contribution of neuronal apoptosis to the above-mentioned disorders, potential clinical applications and their limitations and the possible implications for future studies regarding these neurodegenerative diseases.

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