Open AccessInfluence of Isoflurane Concentration and Hypoxia on Functional Magnetic Resonance Imaging for the Detection of Bicuculline-Induced Neuronal Activation
Author(s) -
Masahiro Abo,
Masahiko Suzuki,
Atushi Senoo,
Satoshi MIYANO,
Hideki Yamauchi,
Kyozo YONEMOTO,
Shu Watanabe,
Lars Edström
Publication year - 2004
Publication title -
neurosignals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.755
H-Index - 67
eISSN - 1424-8638
pISSN - 1424-862X
DOI - 10.1159/000076568
Subject(s) - bicuculline , isoflurane , magnetic resonance imaging , functional magnetic resonance imaging , anesthesia , functional magnetic resonance spectroscopy of the brain , cerebral blood volume , blood oxygenation , hypoxia (environmental) , stimulation , chemistry , neuroscience , medicine , oxygen , cerebral blood flow , psychology , radiology , gabaa receptor , receptor , organic chemistry
Our present study shows that transient changes in relative cerebral blood volume (rCBV) induced by stimulation with bicuculline under six different conditions of anesthesia can be detected with high spatial resolution functional magnetic resonance imaging (fMRI). Bicuculline was administered at a low dose to induce neural activation, and no seizure activity was noted. Of the six conditions, the maximal reaction to bicuculline was observed under 1.5% isoflurane in 60% nitrogen and 40% oxygen. Our results imply that the rCBV changes under this level of isoflurane anesthesia with body temperature maintained at 37.5 degrees C are probably suitable for further fMRI studies.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom