Interleukin-1 and Nitric Oxide Increase NADPH Oxidase Activity in Human Coronary Artery Smooth Muscle Cells | Zendy

Jaspal Kaur | Zendy; Gursev S. Dhaunsi | Zendy; Ronald B. Turner | Zendy

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Interleukin-1 and Nitric Oxide Increase NADPH Oxidase Activity in Human Coronary Artery Smooth Muscle Cells

Author(s) -

Jaspal Kaur,

Gursev S. Dhaunsi,

Ronald B. Turner

Publication year - 2003

Publication title -

medical principles and practice

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.426

H-Index - 45

eISSN - 1423-0151

pISSN - 1011-7571

DOI - 10.1159/000074047

Subject(s) - superoxide , nadph oxidase , nitric oxide , sodium nitroprusside , medicine , reactive oxygen species , vascular smooth muscle , oxidase test , pharmacology , biochemistry , oxidative stress , enzyme , chemistry , smooth muscle

Cytokines, nitric oxide (NO) and reactive oxygen species (ROS) are well known for their pathogenic effects in development of cardiovascular diseases. Interleukin-1beta (IL-1beta) is known to induce NO generation, however it is not well established if IL-1beta or NO regulate production of ROS, such as superoxide anion. Therefore, the main objective of this study was to evaluate the effect of IL-1beta or NO on enzyme activity of NADPH oxidase (NOX), a superoxide-generating system recently documented to participate in a variety of vascular functions.

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