Changes in Bone Density during Long-Term Administration of Low-Molecular-Weight Heparins or Acenocoumarol for Secondary Prophylaxis of Venous Thromboembolism | Zendy

L Wawrzyńska | Zendy; Witold Tomkowski | Zendy; J Przedlacki | Zendy; B Hajduk | Zendy; Adam Torbicki | Zendy

Open Access

Changes in Bone Density during Long-Term Administration of Low-Molecular-Weight Heparins or Acenocoumarol for Secondary Prophylaxis of Venous Thromboembolism

Author(s) -

L Wawrzyńska,

Witold Tomkowski,

J Przedlacki,

B Hajduk,

Adam Torbicki

Publication year - 2003

Publication title -

pathophysiology of haemostasis and thrombosis

Language(s) - English

Resource type - Journals

eISSN - 1424-8840

pISSN - 1424-8832

DOI - 10.1159/000073848

Subject(s) - acenocoumarol , medicine , densitometry , osteoporosis , bone mineral , low molecular weight heparin , anticoagulant , surgery , heparin , bone density , concomitant , warfarin , anesthesia , atrial fibrillation

Indications for long-term anticoagulation are expanding. Osteoporosis is a complication which can develop after prolonged treatment with unfractionated heparin and is probably multifactorial. Data on osteoporosis associated with low-molecular-weight heparins (LMWH) are contradictory. Vitamin K participates in bone metabolism and since oral anticoagulants antagonize vitamin K, their use may also increase the risk of osteoporosis.

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