Air pollution and thrombosis: an experimental approach | Zendy

Abderrahim Nemmar | Zendy; Benoît Nemery | Zendy; Marc Hoylaerts | Zendy; Jos Vermylen | Zendy

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Air pollution and thrombosis: an experimental approach

Author(s) -

Abderrahim Nemmar,

Benoît Nemery,

Marc Hoylaerts,

Jos Vermylen

Publication year - 2002

Publication title -

pathophysiology of haemostasis and thrombosis

Language(s) - English

Resource type - Journals

eISSN - 1424-8840

pISSN - 1424-8832

DOI - 10.1159/000073597

Subject(s) - icon , download , citation , thrombosis , medicine , information retrieval , library science , computer science , bioinformatics , world wide web , surgery , biology , programming language

Air pollution is associated with cardiovascular mortality. Inhaled ultrafine particles translocate into the blood. Amine-polystyrene ultrafine particles significantly enhance experimental thrombus formation in a damaged hamster vessel and shorten the closure time in the Platelet Function Analyser. Diesel exhaust particles are thrombogenic within one hour of intratracheal instillation and shorten the closure time ex vivo. These experimental observations provide a plausible biological explanation for the epidemiologically established link between air pollution and acute myocardial infarction.

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