Effects of Erythropoietin-Gene Electrotransfer in Rats with Adenine-Induced Renal Failure | Zendy

Ken Ataka | Zendy; Hiroki Maruyama | Zendy; Tomohiro Neichi | Zendy; Junichi Miyazaki | Zendy; Fumitake Gejyo | Zendy

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Effects of Erythropoietin-Gene Electrotransfer in Rats with Adenine-Induced Renal Failure

Author(s) -

Ken Ataka,

Hiroki Maruyama,

Tomohiro Neichi,

Junichi Miyazaki,

Fumitake Gejyo

Publication year - 2003

Publication title -

american journal of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 85

eISSN - 1421-9670

pISSN - 0250-8095

DOI - 10.1159/000072913

Subject(s) - erythropoietin , hematocrit , uremia , medicine , anemia , endocrinology , erythropoiesis , electroporation , kidney disease , gene , biology , biochemistry

We previously demonstrated that erythropoietin (Epo) expression increases in five-sixths nephrectomized rats, after muscle-targeted gene transfer by in vivo electroporation, using plasmid DNA expressing rat Epo (pCAGGS-Epo). Here, we apply this method to a rat model with severe anemia associated with chronic renal failure; these rats have hematocrit levels in the 30-35% range, similar to those in humans with end-stage renal disease.

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