Effects of an Angiotensin II Receptor Antagonist and Angiotensin-Converting Enzyme Inhibitors on Burst Forming Units-Erythroid in Chronic Hemodialysis Patients | Zendy

Masayo Naito | Zendy; Akira Kawashima | Zendy; Takashi Akiba | Zendy; Minoko Takanashi | Zendy; Hiroshi Nihei | Zendy

Open Access

Effects of an Angiotensin II Receptor Antagonist and Angiotensin-Converting Enzyme Inhibitors on Burst Forming Units-Erythroid in Chronic Hemodialysis Patients

Author(s) -

Masayo Naito,

Akira Kawashima,

Takashi Akiba,

Minoko Takanashi,

Hiroshi Nihei

Publication year - 2003

Publication title -

american journal of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 85

eISSN - 1421-9670

pISSN - 0250-8095

DOI - 10.1159/000072705

Subject(s) - hemodialysis , medicine , endocrinology , erythropoietin , angiotensin ii receptor type 1 , receptor antagonist , peripheral blood mononuclear cell , angiotensin ii receptor antagonist , angiotensin ii , antagonist , hematocrit , receptor , pharmacology , angiotensin receptor , chemistry , in vitro , biochemistry

Angiotensin-converting enzyme (ACE) inhibitors have been reported to reduce the response to erythropoietin (EPO) administration in chronic hemodialysis patients, but the mechanism for this effect has not yet been clarified. To clarify the mechanism of ACE inhibitors- and angiotensin II type 1 (AT1) receptor antagonist-induced anemia in hemodialysis patients, we examined the effect of ACE inhibitors and AT1 receptor antagonist on burst-forming units-erythroid (BFU-E) in the peripheral blood of hemodialysis patients and healthy controls in vitro.

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