Polymorphisms of the NADPH Oxidase p22phox Gene in a Caucasian Population with Intracranial Aneurysms | Zendy

Dietmar Krex | Zendy; Andreas Ziegler | Zendy; Inke R. König | Zendy; Hans K. Schackert | Zendy; Gabriele Schackert | Zendy

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Polymorphisms of the NADPH Oxidase <i>p22phox</i> Gene in a Caucasian Population with Intracranial Aneurysms

Author(s) -

Dietmar Krex,

Andreas Ziegler,

Inke R. König,

Hans K. Schackert,

Gabriele Schackert

Publication year - 2003

Publication title -

cerebrovascular diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.221

H-Index - 104

eISSN - 1421-9786

pISSN - 1015-9770

DOI - 10.1159/000072558

Subject(s) - p22phox , haplotype , locus (genetics) , genotype , medicine , nadph oxidase , allele , gastroenterology , population , allele frequency , pathology , genetics , microbiology and biotechnology , gene , biology , oxidative stress , environmental health

Vascular remodeling generated by reactive oxygen species contributes to aneurysm formation. The NADPH oxidase system is a major source of superoxide anion not only in phagocytes, but also in endothelial and vascular smooth muscle cells. Polymorphisms of p22phox, an essential component of the NADPH oxidase system, are found to be associated with atherosclerosis, while a recent study found a significant association between the 214C>T polymorphism and the occurrence of ischemic cerebrovascular disease. We conducted a case-control study to investigate the relationship of five polymorphisms of the P22PHOX gene and the occurrence of cerebral aneurysms.

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