Proceedings: Pathogenesis and Treatment of Renal Osteodystrophy | Zendy

Eduardo Slatopolsky | Zendy; Esther Mena Gonzalez | Zendy; Kévin Martin | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Proceedings: Pathogenesis and Treatment of Renal Osteodystrophy

Author(s) -

Eduardo Slatopolsky,

Esther Mena Gonzalez,

Kévin Martin

Publication year - 2003

Publication title -

blood purification

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.686

H-Index - 57

eISSN - 1421-9735

pISSN - 0253-5068

DOI - 10.1159/000072552

Subject(s) - renal osteodystrophy , medicine , endocrinology , parathyroid hormone , bone remodeling , calcitriol , bone disease , calcium metabolism , kidney disease , vitamin d and neurology , pathogenesis , calcium , osteoporosis

Renal osteodystrophy is the term used to describe the many different patterns of the skeletal abnormalities that occur in patients with chronic kidney disease. The main two conditions are osteitis fibrosa, characterized by high bone turnover, increased osteoclastic and osteoblastic activity, and high levels of circulating parathyroid hormone (PTH) and adynamic bone disease characterized by low bone turnover and low levels of circulating PTH. Retention of phosphorus, decreased levels of calcitriol in blood, decreased levels of serum ionized calcium, reduced numbers of vitamin D receptors and calcium sensors in the parathyroid gland, and skeletal resistance to the calcemic action of PTH play a major role in the development of renal osteodystrophy. This review will describe the current approach for the treatment of renal osteodystrophy.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research