Angiotensin-Converting Enzyme Inhibition Induces Death Receptor Apoptotic Pathways in Erythroid Precursors following Renal Transplantation | Zendy

Ilya Glezerman | Zendy; Hiren Patel | Zendy; Daniel Glicklich | Zendy; H Croizat | Zendy; Prasad Devarajan | Zendy

Open Access

Angiotensin-Converting Enzyme Inhibition Induces Death Receptor Apoptotic Pathways in Erythroid Precursors following Renal Transplantation

Author(s) -

Ilya Glezerman,

Hiren Patel,

Daniel Glicklich,

H Croizat,

Prasad Devarajan

Publication year - 2003

Publication title -

american journal of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 85

eISSN - 1421-9670

pISSN - 0250-8095

DOI - 10.1159/000071188

Subject(s) - fadd , medicine , tradd , transplantation , kidney , caspase 8 , endocrinology , apoptosis , fas receptor , angiotensin converting enzyme , caspase 3 , programmed cell death , caspase , biology , death domain , biochemistry , blood pressure

Posttransplant erythrocytosis (PTE) is a condition that occurs in kidney transplant patients and is characterized by increase in hematocrit above 51%. While its pathogenesis remains unclear, angiotensin-converting enzyme inhibitors (ACEI) have been used successfully in the treatment of PTE. We have previously shown that ACEI induce apoptosis in the peripheral erythroid precursors from patients with PTE. In the current study we elucidate the molecular mechanisms of ACEI-induced apoptosis.

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