Effect of Phenprocoumon on Monitoring of Lepirudin, Argatroban, Melagatran and Unfractionated Heparin with the PiCT Method | Zendy

Tivadar Fenyvesi | Zendy; Ingrid Jörg | Zendy; Job Harenberg | Zendy

Open Access

Effect of Phenprocoumon on Monitoring of Lepirudin, Argatroban, Melagatran and Unfractionated Heparin with the PiCT Method

Author(s) -

Tivadar Fenyvesi,

Ingrid Jörg,

Job Harenberg

Publication year - 2002

Publication title -

pathophysiology of haemostasis and thrombosis

Language(s) - English

Resource type - Journals

eISSN - 1424-8840

pISSN - 1424-8832

DOI - 10.1159/000070423

Subject(s) - lepirudin , argatroban , discovery and development of direct thrombin inhibitors , phenprocoumon , heparin induced thrombocytopenia , direct thrombin inhibitor , chemistry , pharmacology , heparin , clot formation , anticoagulant , thrombin , medicine , coagulation , biochemistry , warfarin , platelet , dabigatran , atrial fibrillation

Prothrombinase-induced clotting time (PiCT) is a clotting-time test for heparins and direct thrombin inhibitors to reduce drawbacks of aPTT. Effects of the direct thrombin inhibitors lepirudin, argatroban, melagatran and of unfractionated heparin (UFH) were investigated in normal and oral anticoagulant plasma samples. Lepirudin showed potentiating interferences with phenprocoumon effects. Melagatran, argatroban and UFH delivered distinct linear additive effects in both plasma sample groups. PiCT ratio reduces differences between both groups with UFH, and argatroban inhibitor-receptor-binding mode plays a role in interaction patterns.

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