Argatroban in Thrombotic Stroke | Zendy

Marian P. LaMonte | Zendy

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Argatroban in Thrombotic Stroke

Author(s) -

Marian P. LaMonte

Publication year - 2002

Publication title -

pathophysiology of haemostasis and thrombosis

Language(s) - English

Resource type - Journals

eISSN - 1424-8840

pISSN - 1424-8832

DOI - 10.1159/000069108

Subject(s) - argatroban , medicine , stroke (engine) , thrombin , cerebral blood flow , discovery and development of direct thrombin inhibitors , cardiology , ischemic stroke , ischemia , platelet , mechanical engineering , engineering

Evidence for the potential use of direct thrombin inhibition in the treatment of acute stroke is reviewed. Reduction of secondary microthrombi and improved regional collateral cerebral blood flow is the proposed mechanism of action of thrombin inhibition for the treatment of cerebral ischemia. A clinical study in Japan found that argatroban administered within 48 h of stroke symptom onset is safe and effective in reducing neurological impairment due to ischemic stroke. The implications of further clinical studies are discussed.

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