Polymorphic Genes for Kinin Receptors, Nephropathy and Blood Pressure in Type 2 Diabetic Patients
Author(s) -
Marcin Zychma,
Janusz Gumprecht,
Wanda Trautsolt,
Ilona Szydlowska,
W Grzeszczak
Publication year - 2003
Publication title -
american journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 85
eISSN - 1421-9670
pISSN - 0250-8095
DOI - 10.1159/000068035
Subject(s) - microalbuminuria , medicine , endocrinology , diabetic nephropathy , nephropathy , blood pressure , diabetes mellitus
There is evidence that hereditary predisposition contributes to the development of diabetic nephropathy and hypertension. Polymorphisms in the genes for bradykinin receptors (B(1)R and B(2)R) were found to be associated with decreased risk of the development of end-stage renal disease. This study examines whether B(1)R G(-699)C and B(2)R C(181)T polymorphisms are associated with microalbuminuria or overt nephropathy, or blood pressure variation in type 2 diabetic subjects.
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